This site is focused on:-

1) The Fluids of the Inner Ear, perilymph and endolymph

2) The Barriers of the Ear, controlling how substances enter and leave the ear

3) Local Drug Delivery to the Inner Ear

4) Computer Simulations of Drug Distribution in the Ear

Iillustrations at the top are:

(Left) A guinea pig inner ear in which the perilymphatic spaces were filled with orange latex and the endolymph space with dark blue latex. The ear was then dissected open. When this was performed back in the 1980's, this was our first ever 3D view of the inner ear fluid spaces.

(Middle) Digital 3D reconstruction of the fluid spaces of the guinea pig ear generated from virtual slices obtained with an optical sectioning technique. Yellow:scala tympani; Green: scala vestibuli; Blue:endolymph; Cyan: round window; Brown: stapes. This allows us to accurately quantify the dimensions of each of the fluid and tissue spaces of the ear for use in computer models.

(Right) A mid-modiolar histologic section through the guinea pig ear, detailing the membranous and cellular structures inside. 

 

The Salt Lab has moved to Turner Scientific, who specialize in pharmacokinetic studies related to hearing. We plan to make Turner  Scientific the world leader of the inner ear drug therapy pipeline.

 

The FluidSim Cochlear Fluids Simulator is back !!

Now available on the FluidSim page