(updated July 20, 2023)
The link takes you to a Google Drive.
There are 3 files on the drive:
1) FluidSimBaseFiles.zip : If you have never run FluidSim before, you need to first download this folder and unzip it to a directory (call it FluidSim) in a convenient place (e.g desktop or documents directory). This contains all the data files the program requires to run.
2) FluidSim406PC.zip : This is the windows version of the program. Unzip the folder and move it's contents (all the files and folders within) to the FluidSim directory. The program file should be in the FluidSim directory and not in a sub-folder..
3) FluidSim406.app.zip : This is the Mac version of the program. Download and drag the app to the FluidSim folder. Do not change it in any way (do not rename it). Also see the additional instructions below concerning Mac security.
If you already have FluidSim on your machine, you can update the program without changing the setup files by just downloading the version of the program that you need (i.e. skip the Basefiles download). It is recommended that you make a copy of your present FluidSim folder first.
A Manual for running the program is included in the basefiles download and includes more detailed instruction for running the program.
FluidSim is a computer program that represents drug distribution in the inner ear. It is intended to help design and interpret inner ear drug delivery experiments in animals and to predict the distribution of drugs in the human ear. It can be useful to justify therapeutic protocols to the FDA. It is currently the most sophisticated simulation of drug distribution in the ear available.
The program can set up kinetic parameters of the drug molecule you are using. For the limited number of substances for which PK data are available (dexamethasone, gentamicin, etc), kinetic parameters are set based on the measured data. For other drugs, kinetic parameters are calculated based on the molecular properties (WLOGP and TPSA) of the substance, which can be determined for any substance.
It simulates intratympanic applications, direct injections into perilymph or endolymph, drug elution from cochlear implants and systemic and intrathecal applications. It simulates common measurement methods through fluid sampling. It can calculate for ears the size of the Human, Guinea Pig, Mouse or Cat.
NOTE: If you are installing on a MAC, when you run the app you will probably get a message such as:
You can allow it to run by going to System Preferences>Security and Privacy> General Page. If you unlock the page you should see:
Select the "Open Anyway" option. The program will now be allowed to run and you will not have to do this again. I would also like to point out that I am a registered Apple developer and the code was signed with a certificate (otherwise you would not have got this far). But that is the way it is.